Show simple item record Popat, Roman Crusz, Shanika A. Messina, Marco Williams, Paul West, Stuart A. Diggle, Stephen P. 2012-12-10T18:42:39Z 2012-12-10T18:42:39Z 2012-10-03
dc.identifier doi:10.5061/dryad.vg0b5
dc.identifier.citation Popat R, Crusz SA, Messina M, Williams P, West SA, Diggle SP (2012) Quorum sensing and cheating in bacterial biofilms. Proceedings of the Royal Society B 279(1748): 4765-4771.
dc.description The idea from human societies that self-interest can lead to a breakdown of cooperation at the group level is sometimes termed the public goods dilemma. We tested this idea in the opportunistic bacterial pathogen, Pseudomonas aeruginosa, by examining the influence of putative cheats that do not cooperate via cell-to-cell signalling (quorum-sensing, QS). We found that: (i) QS cheating occurs in biofilm populations owing to exploitation of QS-regulated public goods; (ii) the thickness and density of biofilms was reduced by the presence of non-cooperative cheats; (iii) population growth was reduced by the presence of cheats, and this reduction was greater in biofilms than in planktonic populations; (iv) the susceptibility of biofilms to antibiotics was increased by the presence of cheats; and (v) coercing cooperator cells to increase their level of cooperation decreases the extent to which the presence of cheats reduces population productivity. Our results provide clear support that conflict over public goods reduces population fitness in bacterial biofilms, and that this effect is greater than in planktonic populations. Finally, we discuss the clinical implications that arise from altering the susceptibility to antibiotics.
dc.relation.haspart doi:10.5061/dryad.vg0b5/1
dc.relation.isreferencedby doi:10.1098/rspb.2012.1976
dc.relation.isreferencedby PMID:23034707
dc.subject Quorum sensing
dc.subject Biofilms
dc.subject Public goods
dc.subject Spatial structure
dc.subject Cooperation
dc.subject Cheating
dc.title Data from: Quorum sensing and cheating in bacterial biofilms
dc.type Article
dwc.ScientificName Pseudomonas aeruginosa
dc.contributor.correspondingAuthor Popat, Roman
prism.publicationName Proceedings of the Royal Society B

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